Explore our favourite publications from past to present.

P2X3-IR fibers represent a subpopulation of PGP-IR fibers in the skin.

Skin Innervation and Peripheral Fibers

  • mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. J Clin Invest.2022 View Abstract

  • Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. Brain Struct Funct.2018 3;223: 1149-1164. View Abstract

  • Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers. Pain. 2017 12;158: 2329-2339. View Abstract 
  • Peripheral nerve injury leads to the establishment of a novel pattern of sympathetic fibre innervation in the rat skin. J Comp Neurol. 2000 2;422: 287-96. View Abstract 
  • Autonomic fiber sprouting in the skin in chronic inflammation. Mol Pain. 2008 4: 56. View Abstract 
  • Distribution of P2X(3)-immunoreactive fibers in hairy and glabrous skin of the rat. J Comp Neurol. 2009 6;514: 555-66. View Abstract 
  • Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model. J Comp Neurol. 2011 1;519: 49-63. View Abstract 
  • Neurotrophic factor changes in the rat thick skin following chronic constriction injury of the sciatic nerve. Mol Pain. 2012 8: 1. View Abstract 


  • Dorsal horn disinhibition and movement-induced behaviour in a rat model of inflammatory arthritis. Rheumatology (Oxford). 2021 2;60: 918-928. View Abstract 
  • Peripheral and central nervous system alterations in a rat model of inflammatory arthritis. Pain.2020 7;161: 1483-1496. View Abstract 
  • Pain-related behavior is associated with increased joint innervation, ipsilateral dorsal horn gliosis, and dorsal root ganglia activating transcription factor 3 expression in a rat ankle joint model of osteoarthritis. Pain Rep. 2020 5;5: e846. View Abstract
  • Sympathetic fiber sprouting in inflamed joints and adjacent skin contributes to pain-related behavior in arthritis. J Neurosci. 2013 24;33: 10066-74. View Abstract 
Healthy tibio-talar joint of the rat hind paw. Stained using Safranin O technique.
NPY was not expressed by IB4 binding sensory neurons after CCI. The presence of NPY (in green) in IB4 binding primary afferents (in red) was assessed in the trigeminal ganglia (TG) after CCI.

Neuropathic Pain

  • Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain. Nat Commun.2022 1;13: 843. View Abstract

  • Microglia Mediate Loss of Spinal Cord Inhibitory Synapses in Neuropathic Pain. Cell Rep. 2021. View Abstract
  • Enhancing neuronal chloride extrusion rescues alpha2/alpha3 GABAA-mediated analgesia in neuropathic pain. Nat Commun.2020 1;11: 869. View Abstract
  • Novel expression pattern of neuropeptide Y immunoreactivity in the peripheral nervous system in a rat model of neuropathic pain. Mol Pain. 2015 11: 31. View Abstract 
  • Sympathetic fibre sprouting in the skin contributes to pain-related behaviour in spared nerve injury and cuff models of neuropathic pain. Mol Pain. 2015 11: 59. View Abstract 

Pain Mechanisms

  • Microglia-mediated degradation of perineuronal nets promotes pain. Science.2022 eabl6773. View Abstract

  • Long-term male-specific chronic pain via telomere- and p53mediated spinal cord cellular senescence. J Clin Invest.2022 8;132: View Abstract

  • Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. Brain Struct Funct. 2018 3;223: 1149-1164. View Abstract 
  • Epiregulin and EGFR interactions are involved in pain processing. J Clin Invest. 2017 9;127: 3353-3366. View Abstract 
  • Optogenetic Silencing of Nav1.8-Positive Afferents Alleviates Inflammatory and Neuropathic Pain. eNeuro. 2016 1;3: View Abstract 
  • eIF2alpha phosphorylation controls thermal nociception. Proc Natl Acad Sci U S A. 2016 42;113: 11949-11954. View Abstract 
  • Limited changes in spinal lamina I dorsal horn neurons following the cytotoxic ablation of non-peptidergic C-fibers. Mol Pain. 2015 11: 54. View Abstract 
  • Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury. Cell Rep. 2015 6;13: 1246-1257. View Abstract 
  • Control of P2X3 channel function by metabotropic P2Y2 utp receptors in primary sensory neurons. Mol Pharmacol. 2013 3;83: 640-7. View Abstract 
  • Inhibition of endogenous NGF degradation induces mechanical allodynia and thermal hyperalgesia in rats. Mol Pain. 2013 9: 37. View Abstract 
  • Remote optogenetic activation and sensitization of pain pathways in freely moving mice. J Neurosci. 2013 47;33: 18631-40. View Abstract 
Confocal images at high magnification showing the morphology and NK-1r expression by the lamina I spinoparabrachial neuronal population in IB4-saporin-injected animals
Micrograph showing co-localization of alpha 1 adrenoreceptor and TRPV1 immunolabeling (whit arrows head) in suburothelial nerve fibers of control animals.


  • Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1. Sci Rep.2021 1;11: 15490. View Abstract

  • Differential Coding of Itch and Pain by a Subpopulation of Primary Afferent Neurons. Neuron.2020 6;106: 940-951 e4. View Abstract

  • TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell.2020 5;180: 956-967 e17. View Abstract

  • Behavioral signs of pain and functional impairment in a mouse model of osteogenesis imperfecta. Bone.2015 81: 400-406. View Abstract 
  • Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis. Nat Med.2014 10;20: 1165-73. View Abstract 
  • Can the adrenergic system be implicated in the pathophysiology of bladder pain syndrome/interstitial cystitis? A clinical and experimental study. Neurourol Urodyn.2015 5;34: 489-96. View Abstract 
  • Impact of the NGF maturation and degradation pathway on the cortical cholinergic system phenotype. J Neurosci.2012 6;32: 2002-12. View Abstract